Journal of medicinal chemistry

Preparation and antiinflammatory activity of some 2-arylbenzo [b] thiophen-3 (2H)-one 1, 1-dioxides

JG Lombardino, EH Wiseman

文献索引：Lombardino,J.G.; Wiseman,E.H. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 206 - 210

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被引用次数: 14

摘要

17titl -uccesduI heparution oi :inticoagulant uctivitj trom :ititiinflamm:ttor!- nctivit j in :I group of 2-ttryl- 1 .3-iiid:indiorieh1 ? prompted the preparation of a wrie- oi 2-;ir~ lberizo [b ]thiopheii-~(2H)-,,ii, 1 .l-dioxide- The-e were evaluated for both anticoagulant (inhibitioli of prothrombin syrithesi-) arid antiinflammatory (iii- Iiibit ioti of carrageeIiin-induced rat foot edema) :IC- I ivjtic-. After determining that> 2-phenylbenzo [blthio- phun-S(2H)-one 1 .l-dioxide (1) ...