Enzymatic kinetic resolution of hydroxystearic acids: A combined experimental and molecular modelling investigation

…, P Caruana, G Micheletti, N Calonghi, L Masotti

文献索引：Ebert, Cynthia; Felluga, Fulvia; Forzato, Cristina; Foscato, Marco; Gardossi, Lucia; Nitti, Patrizia; Pitacco, Giuliana; Boga, Carla; Caruana, Paolo; Micheletti, Gabriele; Calonghi, Natalia; Masotti, Lanfranco Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 83, p. 38 - 45

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被引用次数: 5

摘要

Enantioenriched 7-, 8-, 9-, and 10-hydroxystearic acids (HSA) were obtained, for the first time, by kinetic resolution of their racemates with lipases CALB and PS, in the presence of vinyl acetate. Among them, the best results were obtained for 7-HSA and 9-HSA, whose enantiomeric excess was around 55%. The same resolutions carried out on the hydroxy esters completely failed. For the acid substrates neither the Kazlauskas' rule nor the 3D- ...