Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides

…, JM Nicholson, O Bakare, RJ Butcher, TL Wilson…

文献索引：Anderson, Alan J.; Nicholson, Jesse M.; Bakare, Oladapo; Butcher, Ray J.; Wilson, Tiffany L.; Scott Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 4 p. 997 - 1006

全文：HTML全文

被引用次数: 11

摘要

Structure–activity relationship studies were employed to synthesize a series of 3-and 3, 4- substituted benzamides from 3-amino-2-cyclohexenones. An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented which provided significantly higher yields (71–79%) for the reported compounds. NMR and X-ray structural analyses were undertaken to note the possible intra-and intermolecular interactions of the ...