Abstract Some new liquid crystalline 2, 5-disubstituted 1, 3, 4-thiadiazole derivatives incorporating a central group (− CH= N−) have been synthesized by treating 2-amino-5-(4- alkoxyphenyl)-1, 3, 4-thiadiazole with corresponding p-alkoxybenzaldehyde. Their structures have been characterized with Elementary Analysis, IR, 1HNMR and MS, and their properties were determined by using DSC and Texture. All 12 compounds are ...