前往化源商城

Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1, 3-thiazol-5-yl]-2-pyridyl] benzamide (TAK-715) as a potent …

…, H Kimura, T Tanaka, S Asahi, S Ohkawa

文献索引:Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979

全文:HTML全文

被引用次数: 129

摘要

The p38 mitogen-activated protein (MAP) kinase has been implicated in the proinflammatory cytokine signal pathway, and its inhibitors are potentially useful for the treatment of chronic inflammatory diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease. To develop a new drug for RA, we synthesized a novel series of 4-phenyl-5-pyridyl-1, 3- thiazoles and evaluated their inhibition of p38 MAP kinase, lipopolysaccharide (LPS)- ...

 相关合成线路

~71%

~%

~%

~%

~%

~%

~%

~86%

~%

~%

~%

~35%

~%

~%

~%

~%

~76%

~%

~%

~%

~71%

~%

~%

~%

~%

~%

~%

~%

~68%

~91%

~%

~%

~%

~%

~%

~%

~76%

~%

~%

~%

~76%

~%

~%

~%

~65%

~%

~%

~%

~%

~%

~%

~%

~53%

~76%

~%

~%

~%

~%

~%

~%

~%

~38%

~%

~%

~%

~%

~%