Tetraazaacenaphthene, tetraazaphenalene and 1, 3, 4-thiadiazole derivatives as potential leishmanicides

VJ Ram, A Goel, M Kandpal, N Mittal, N Goyal…

文献索引：Ram; Goel; Kandpal; Mittal; Goyal; Tekwani; Guru; Rastogi Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 651 - 656

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被引用次数: 9

摘要

Synthesis and leishmanicidal activity of 1, 3-dithiolanes (2a, b), 1, 3-dithiane (2c), tetraazaacenaphthene (4a-h) and tetraazaphenalene (4i, j), imidazolidin-2-ylidene (5a, 6a, b) and hexahydropyrimidin-2-ylidene (5b) derivatives are described. Some of the screened compounds have demonstrated significant leishmanicidal activity in in vitro and in vivo evaluations.