A convenient asymmetric synthesis of α-1-arylalkylamines through the enantioselective hydrogenation of enamides

MJ Burk, YM Wang, JR Lee

文献索引：Burk, Mark J.; Wang, Yan Ming; Lee, Jeffrey R. Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 5142 - 5143

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被引用次数: 213

摘要

Optically active R-1-arylalkylamines constitute an important class of compounds that have been employed extensively as resolving agents, 1 chiral auxiliaries, and intermediates in the synthesis of a wide range of biologically active molecules. 2 The broad utility of R-1- arylalkylamine derivatives has stimulated relentless pursuit of practical asymmetric routes to these valuable compounds. In this regard, many reliable synthetic methods have been ...