Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

JT Whitteck, W Ni, BM Griffin, AC Eliot…

文献索引：Whitteck, John T.; Ni, Weijuan; Griffin, Benjamin M.; Eliot, Andrew C.; Thomas, Paul M.; Kelleher, Neil L.; Metcalf, William W.; Van Der Donk, Wilfred A. Angewandte Chemie - International Edition, 2007 , vol. 46, # 47 p. 9089 - 9092

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被引用次数: 27

摘要

Antibiotic biosynthesis has enjoyed a renewed interest in recent years, with most efforts directed at polyketide synthases, non-ribosomal peptide synthetases, and antimicrobial peptides.[1, 2] Relatively unexplored with respect to biosynthetic pathways are phosphonate antibiotics, despite their commercial use as pharmaceuticals, herbicides, and pesticides.[3– 5] In fact, currently the biosynthetic pathways of only three phosphonate antibiotics are ...