Tetrahedron letters

Stereochemical assignment of the fungal metabolite xestodecalactone A by total synthesis

G Bringmann, G Lang, M Michel, M Heubes

文献索引：Bringmann, Gerhard; Lang, Gerhard; Michel, Manuela; Heubes, Markus Tetrahedron Letters, 2004 , vol. 45, # 13 p. 2829 - 2831

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被引用次数: 25

摘要

The first synthesis of the macrocyclic natural product xestodecalactone A, a metabolite of a sponge-derived fungus, is described. By the use of methyl 5-hydroxyhexanoate in its R-or S- configured form, or as its racemate as the precursors, both enantiomers of xestodecalactone A as well as the racemic compound were obtained. Comparison of these synthetic products with the natural product by circular dichroism (CD) spectroscopy and by HPLC on a chiral ...