Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors

…, X Chen, Z Wu, Y Zheng, Y Chen, W Tang, T Lu

文献索引：Zhu, Yong; Chen, Xin; Wu, Zeng; Zheng, Yixuan; Chen, Yadong; Tang, Weifang; Lu, Tao Archives of Pharmacal Research, 2012 , vol. 35, # 10 p. 1723 - 1732

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被引用次数: 4

摘要

Abstract A series of diaryl ether hydroxamic acids were synthesized for the first time and evaluated for the HDAC biology and antiproliferative activity. The structures of these new hydroxamic acids derivatives were confirmed by IR, 1 H-NMR and mass spectrum. Some of these compounds showed micro molar activity in the HDAC inhibitory assay and against four cancer cell lines.