Synthesis of new 2, 4-diamino-5-benzylpyrimidines active against various bacterial species

M Kansyl, JK Seydel, M Wiese, R Haller

文献索引：Kansy, M; Seydel, JK; Wiese, M; Haller, R European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 237 - 244

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被引用次数: 19

摘要

Abstract New inhibitors of mycobacterial dihydrofolate reductase (DHFR) have been developed. These compounds show high inhibitory activities against Gram-negative and mycobacterial DHFR exceeding that for the commercially available DHFR blockers. Amongst these compounds K-130 shows a 100-fold lower MIC against M lufu than the most active derivatives known so far (TMP, BDP). Mycobacterium lufu was used as a model for ...