Synlett

Zinc metal-promoted cross-coupling reaction of non-activated alkyl halides with aldehydes in the presence of chlorotrimethylsilane

T Ito, Y Ishino, T Mizuno, A Ishikawa, J Kobayashi

文献索引：Ito, Takatoshi; Ishino, Yoshio; Mizuno, Takumi; Ishikawa, Akira; Kobayashi, Jun-Ichi Synlett, 2002 , # 12 p. 2116 - 2118

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被引用次数: 14

摘要

Abstract Treatment of non-activated alkyl halides 1 with aldehydes 3 in the presence of zinc metal and chlorotrimethylsilane (TMSCl), DMA and/or NMP in THF brought about highly facile and effective cross-coupling to give the corresponding alcohols in good yield. These reactions are assumed to proceed through zinc reagent intermediates generated in situ.