Abstract 3-Alkylcarbonyloxymethyl derivatives of 5-fluorouracil have been synthesized starting with 1-ethyloxy-carbonyl-5-fluorouracil. Alkylation of the starting material with alkylcarbonyloxymethyl iodides, generated from the corresponding chlorides by the Finkelstein reaction, in the presence of 1, 8-bis (dimethyl-amino) naphthalene followed by deprotection with 1, 1-dimethylethylamine gave good yields (50-60%) of the target ...
