An Investigation into the Haematological Toxicity of Structural Analogues of Dapsone In??vivo and In??vitro

MD Coleman, MD Tingle, F Hussain…

文献索引：Coleman; Tingle; Hussain; Storr; Park Journal of Pharmacy and Pharmacology, 1991 , vol. 43, # 11 p. 779 - 784

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被引用次数: 20

摘要

Abstract—With microsomes prepared from a single human liver, 4, 4′-diaminodiphenyl sulphone (DDS), 4-acetyl-4-aminodiphenyl sulphone (MADDS), 4-acetyl-4-aminodiphenyl thioether (MADDT) and 4, 4′-diacetyldiphenyl thioether (DADDT) caused significantly greater methaemoglobin formation compared with control. In-vitro in the rat, the pattern of toxicity was slightly different: DADDT was not haemotoxic, whilst 3, 4′-diaminodiphenyl ...