Novel amidino substituted 2-phenylbenzothiazoles: Synthesis, antitumor evaluation in vitro and acute toxicity testing in vivo

…, V Tralić-Kulenović, G Karminski-Zamola

文献索引：Racane, Livio; Kralj, Marijeta; Suman, Lidija; Stojkovic, Ranko; Tralic-Kulenovic, Vesna; Karminski-Zamola, Grace Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1038 - 1044

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被引用次数: 26

摘要

The efficient synthesis of new bis-substituted nitro-amidino, amino-amidino (10a, 10b–13a, 13b) and previously prepared diamidino 2-phenyl-benzothiazoles (9a, 9b) is described. The compounds 11a and 11b were prepared by recently developed methodology of the key precursors in zwitterionic form 8a and 8b with 4-nitrobenzoylchloride in a very good yield (70%). All compounds except diamidino-substituted 2-phenylbenzothiazole 9a show ...