C O Cross??Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols

…, SW Krska, JD Schreier, IT Raheem

文献索引：Maligres, Peter E.; Li, Jing; Krska, Shane W.; Schreier, John D.; Raheem, Izzat T. Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9071 - 9074

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被引用次数: 23

摘要

Aromatic ethers are ubiquitous structural motifs present in both natural and synthetic compounds including dozens of the 200 top-selling drugs on the market today (Figure1).[1] Traditional methods for accessing this functionality, such as direct nucleophilic aromatic substitution (SNAr) and Ullmann coupling, typically require reactive aryl halides or harsh reaction conditions and thus display limited substrate scope and functional-group ...