Improved synthesis of functionalized 2, 2'-bipyrroles

…, E Hao, MGH Vicente, KM Smith

文献索引：Jiao, Lijuan; Hao, Erhong; Vicente, M. Graca H.; Smith, Kevin M. Journal of Organic Chemistry, 2007 , vol. 72, # 21 p. 8119 - 8122

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被引用次数: 29

摘要

A series of 2, 2'-bipyrroles has been efficiently synthesized using an improved synthetic approach based on Pd (0)-catalyzed homocoupling of various 2-iodopyrroles. This new synthetic approach takes place at room temperature and in the presence of water. Functional groups such as formyl, ester, and nitrile are able to survive these reaction conditions. Solvents are found to play an important role in this reaction.