Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs …

MA Avery, KM Muraleedharan, PV Desai…

文献索引：Avery, Mitchell A.; Muraleedharan, Kannoth M.; Desai, Prashant V.; Bandyopadhyaya, Achintya K.; Furtado, Marise M.; Tekwani, Babu L. Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4244 - 4258

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被引用次数: 85

摘要

Artemisinin (1) and its analogues have been well studied for their antimalarial activity. Here we present the antimalarial activity of some novel C-9-modified artemisinin analogues synthesized using artemisitene as the key intermediate. Further, antileishmanial activity of ...