Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents

…, J Zhang, Y Cao, X Chai, Y Zou, Q Wu, D Zhang…

文献索引：Jiang, Yongwei; Zhang, Jun; Cao, Yongbing; Chai, Xiaoyun; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Sun, Qingyan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4471 - 4475

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被引用次数: 22

摘要

On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of 1-(2-(2, 4-difluorophenyl)-2-hydroxy-3-(1H-1, 2, 4-triazol-1-yl) propyl)-1H-1, 2, 4-triazol-5 (4H)-one derivatives were synthesized as fluconazole analogs. Results of the preliminary antifungal tests against eight human pathogenic fungi in vitro showed that these compounds exhibited activities to some extent, and some displayed ...