Chirospecific synthesis of (1S, 3R)-1-amino-3-(hydroxymethyl) cyclopentane, precursor for carbocyclic nucleoside synthesis. Dieckmann cyclization with an. alpha.- …
SC Bergmeier, AA Cobas…
文献索引：Bergmeier, Stephen C.; Cobas, Agustin A.; Rapoport, Henry Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2369 - 2376
Carbocyclic nucleosides are important isosteres of nucleosides. Both chemically and enzymatically they are more stable than nucleosides, and this stability can offer distinct advantages in the therapeutic use of carbocyclic nucleosides. They possess a variety of antiviral'and antineoplastic activities. 2 In recent years these nucleosides have seen potential application as antiviral agents. a4 Most carbocyclic nucleosides are synthetic in ...
