Discovery and preclinical characterization of (+)-3-[4-(1-piperidinoethoxy) phenyl] spiro [indene-1, 1'-indane]-5, 5'-diol hydrochloride: a promising nonsteroidal …

…, H Minato, H Nakagawa, C Kohayakawa…

文献索引：Watanabe, Nobuhide; Ikeno, Akihisa; Minato, Hisao; Nakagawa, Hiroshi; Kohayakawa, Chie; Tsuji, Jun-Ichi Journal of Medicinal Chemistry, 2003 , vol. 46, # 19 p. 3961 - 3964

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被引用次数: 27

摘要

In our studies of the development of a novel class of selective estrogen receptor modulators,(+)-3-[4-(1-piperidinoethoxy) phenyl] spiro [indene-1, 1'-indane]-5, 5'-diol hydrochloride (1) was found to be an estrogen receptor ligand with beneficial effects in rat models for human hot flush. Moreover, 1 was found to have beneficial effects on lipid and bone metabolism while maintaining marginal effects on the uterus and breasts. These ...