9-Aminomethyl-9, 10-dihydroanthracene (amda) analogs as structural probes for steric tolerance in 5-ht 2a and h 1 receptor binding sites

…, PD Mosier, S Peddi, BL Roth, RB Westkaemper

文献索引：Shah, Jitesh R.; Mosier, Philip D.; Peddi, Srinivas; Roth, Bryan L.; Westkaemper, Richard B. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 935 - 938

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被引用次数: 6

摘要

Synthesis, radioligand binding and molecular modeling studies of several 9-aminomethyl-9, 10-dihydroanthracene (AMDA) analogs were carried out to determine the extent of the steric tolerance associated with expansion of the tricyclic ring system and amine substitution at 5- HT2A and H1 receptors. A mixture of (7, 12-dihydrotetraphene-12-yl) methanamine and (6, 11-dihydrotetracene-11-yl) methanamine in a 75–25% ratio was found to have an ...