Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD (P) H: quinone oxidoreductase (NQO1)

T Fryatt, DT Goroski, ZD Nilson, CJ Moody…

文献索引：Fryatt, Tara; Goroski, Dean T.; Nilson, Zachary D.; Moody, Christopher J.; Beall, Howard D. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2195 - 2198

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被引用次数: 33

摘要

The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD (P) H: quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.