Spacer optimization of new conjugates for a melanoma-selective delivery approach

M André, S Tarrit, MJ Couret, MJ Galmier…

文献索引：Andre, Mathieu; Tarrit, Sebastien; Couret, Marie-Joelle; Galmier, Marie-Josephe; Debiton, Eric; Chezal, Jean-Michel; Mounetou, Emmanuelle Organic and Biomolecular Chemistry, 2013 , vol. 11, # 37 p. 6372 - 6384

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被引用次数: 4

摘要

In the search for more selective anticancer drugs, we designed and synthesized seven conjugates varying the structure of the linker connecting the 5-iodo-2′-deoxyuridine (IUdR) to the ICF 01012 melanoma-carrier for potential intratumoural specific drug release. Chemical and in vitro metabolic stability evaluations showed that, except for the ester conjugate (1), the ketal (2b), acetal (2a), carbonate (4) and carbamate (3) conjugates were ...