Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid- …

…, SL Gibson, R Hilf, SR Davies, AR Oseroff…

文献索引：You, Youngjae; Gibson, Scott L.; Hilf, Russell; Davies, Sherry R.; Oseroff, Allan R.; Roy, Indrajit; Ohulchanskyy, Tymish Y.; Bergey, Earl J.; Detty, Michael R. Journal of Medicinal Chemistry, 2003 , vol. 46, # 17 p. 3734 - 3747

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被引用次数: 76

摘要

Water soluble, core-modified porphyrins 1-5 bearing 1-4 carboxylic acid groups were prepared and evaluated in vitro as photosensitizers for photodynamic therapy. The 21, 23- core-modified porphyrins 1-5 gave band I absorption maxima with λmax of 695-701 nm. The number of carboxylic acid groups in the dithiaporphyrins 1-4 had little effect on either absorption maxima (λmax of 696-701 nm for band I) or quantum yields of singlet oxygen ...