Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction.

…, Y Inoue, Y Goto, F Obara, M Isobe, H Hayashi

文献索引：Isobe, Yoshiaki; Tobe, Masanori; Inoue, Yoshifumi; Goto, Yuso; Obara, Fumihiro; Isobe, Masakazu; Hayashi, Hideya Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 309 - 312

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被引用次数: 3

摘要

In order to obtain novel topically applied anti-inflammatory compounds containing an inexpensive anti-oxidative moiety without chirality, we synthesized compound 2c derivatives having a di-tert-butylphenol moiety, and evaluated by topical administration their anti- inflammatory potentials on picryl chloride-(PC) induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure–activity relationship (SAR) studies on the ...