Organic letters

Enantioselective Enolate Protonation in Sulfa–Michael Addition to α-Substituted N-Acryloyloxazolidin-2-ones with Bifunctional Organocatalyst

NK Rana, VK Singh

文献索引：Rana, Nirmal K.; Singh, Vinod K. Organic Letters, 2011 , vol. 13, # 24 p. 6520 - 6523

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被引用次数: 52

摘要

Organocatalytic conjugate addition of thiols to α-substituted N-acryloyloxazolidin-2-ones followed by asymmetric protonation has been studied in the presence of cinchona alkaloid derived thioureas. Both of the enantiomers are accessible with the same level of enantioselectivity using pseudoenantiomeric quinine/quinidine derived catalysts. The addition/protonation products have been converted to useful biologically active molecules.