Microwave-assisted regioselective synthesis of acyclic nucleosides through an alkylating reaction with 2-oxa-1, 4-butanediol diacetate

…, S Han, Z Zhang, M Geng, F Xue

文献索引：Qu, Guirong; Han, Suhui; Zhang, Zhiguang; Geng, Mingwei; Xue, Feng Canadian Journal of Chemistry, 2006 , vol. 84, # 5 p. 819 - 824

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被引用次数: 15

摘要

An efficient and green procedure for the synthesis of purine acyclic nucleosides through microwave-assisted alkylation of various purine nucleobases with 2-oxa-1, 4-butanediol diacetate in the absence of solvent and catalyst is described. The advantages of using this method include its environmental friendliness, simple manipulation, short reaction time, high regioselectivity, and good yields. Key words: acyclic nucleosides, microwave irradiation, ...