Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure-Activity Relationships of 2-Piperazin-1-yl-1 H-benzimidazoles

VI Ognyanov, C Balan, AW Bannon, Y Bo…

文献索引：Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3719 - 3742

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被引用次数: 72

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The majority of the compounds required for our SAR study, represented by structure III, were prepared by two general routes (methods A and B, Scheme 1). In method A, N ...