Abstract 5-Substituted 2-amino-1, 3, 4-thiadiazoles were transformed to their corresponding 2-bromo derivatives. The reaction of the 5-substituted 2-bromo-1, 3, 4-thiadiazoles with N, N- dialkylaminoethylamines or N-methylpiperazine afforded the corresponding amino-1, 3, 4- thiadiazole derivatives. All prepared compounds displayed antihistaminic, anticholinergic, and norepinephrine-potentiating activities.
