Helvetica Chimica Acta

Studies towards the Synthesis of Alkyl N??(4??Nitrophenyl)??3/2??oxomorpholine??2/3??carboxylates

U Trstenjak, J Ilaš, D Kikelj

文献索引：Trstenjak, Uros; Ilas, Janez; Kikelj, Danijel Helvetica Chimica Acta, 2013 , vol. 96, # 11 p. 2160 - 2172

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被引用次数: 2

摘要

Abstract The syntheses of methyl 4-(4-nitrophenyl)-3-oxomorpholine-2-carboxylate (3a) and ethyl 4-(4-nitrophenyl)-2-oxomorpholine-3-carboxylate (5b), important building blocks for the synthesis of factor Xa inhibitor rivaroxaban analogs with potential dual antithrombotic activity, via Rh 2 (OAc) 4-catalyzed O [BOND] H and N [BOND] H carbene insertion reactions are described.