Application of complementary mass spectrometric techniques to the identification of ketoprofen phototransformation products

T Kosjek, S Perko, E Heath, B Kralj…

文献索引：Kosjek, Tina; Perko, Silva; Heath, Ester; Kralj, Bogdan; Zigon, Dusan Journal of Mass Spectrometry, 2011 , vol. 46, # 4 p. 391 - 401

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被引用次数: 29

摘要

Abstract Ketoprofen (KP) is a nonsteroidal anti-inflammatory drug, which during UV irradiation rapidly transforms into benzophenone derivatives. Such transformation products may occur after topical application of KP, which is then exposed to sunlight resulting in a photo-allergic reaction. These reactions are mediated by the benzophenone moiety independently of the amount of allergen. The same reactions will also occur during ...