Direct visual detection of the stereoselectivity of a catalytic reaction

R Eelkema, RA van Delden…

文献索引：Eelkema, Rienk; Van Delden, Richard A.; Feringa, Ben L. Angewandte Chemie - International Edition, 2004 , vol. 43, # 38 p. 5013 - 5016

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被引用次数: 56

摘要

The unique handedness of the essential molecules of life and the key role of homochirality in the development of new drugs [1] is a source of inspiration for numerous efforts to design efficient catalytic procedures to prepare single enantiomers of biologically active compounds.[2] The analysis of the enantioselectivity in the (high-throughput) screening of asymmetric catalysts [3] is often the rate-determining step,[3, 4] despite the introduction of ...