Abstract As part of a programme to discover new inhibitors of prolyl 4-hydroxylase we have tested a series of 2 substituted pyridines where the substituent is not a carboxylic acid. The 2 substituent has been varied from acid mimics through partially ionised groups to non ionised iron-chelating groups. The results indicate that the 2 carboxylate of pyridine 2-carboxylic acid, 3, can be successfully replaced by groups capable of forming a 5-ring chelate with ...
