Synthesis and characterization of the 6-deaza derivative of coenzyme PQQ, methyl 4, 5-dihydro-4, 5-dioxobenz [g] indole-2-carboxylate

…, Y Fukui, M Ogino, S Haranou, M Komatsu…

文献索引：Itoh; Fukui; Ogino; Haranou; Komatsu; Ohshiro Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2788 - 2793

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被引用次数: 23

摘要

The synthesis of the 6-deaza derivative of coenzyme PQQ, methyl 4, 5-dihydro-4, 5- dioxobenz [g] indole-2-carboxylate (4), is described, and its physical and chemical properties are compared to those of the trimethyl ester of PQQ (2) and the methyl ester of 7P- didecarboxy PQQ (3). The synthesis of 4 was achieved by starting with 1-aminonaphthalene and constructing 2-carbomethoxybenz [g] indole (7) by a Japp-Klingemann reaction with ...