One-step synthesis of 4-alkyl-3-aryl-2, 6-dicyanoanilines and their use in the synthesis of highly functionalized 2, 3, 5, 6, 7-and 2, 3, 4, 5, 7-substituted indoles

SP Sawargave, AS Kudale, JV Deore, DS Bhosale…

文献索引：Sawargave, Sangmeshwer P.; Kudale, Ananada S.; Deore, Jaydeep V.; Bhosale, Dattatry S.; Divse, Jaisingh M.; Chavan, Subhash P.; Borate, Hanumant B. Tetrahedron Letters, 2011 , vol. 52, # 42 p. 5491 - 5493

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被引用次数: 10

摘要

A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2, 6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2, 3, 5, 6, 7-and 2, 3, 4, 5, 7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various ...