Cycloalkanones. 4. Antifertility activity

IH Hall, GL Carlson, GS Abernethy…

文献索引：Hall,I.H. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1253 - 1257

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被引用次数: 57

摘要

2, 8-Dibenzylcyclooctanone, 2, 4-dibenzyl-3-pentanone, 2-(2-fluorobenzyl)-8-((~-ethoxy-2- fluorobenzyl) cyclooctanone, and 2, 8-bis (2-methylbenzyl) cyclooctanone were found to inhibit pregnancy completely at 50 mg/kg. The MEDioo for 2, 8-dibenzylcyclooctanone in CFl mice was 28 mg/kg while the MEDloo for Sprague-Dawley rats was< 1 mg/kg. These compounds had no effect on male fertility