Synthesis and antimicrobial activity of N-[5-(4-t-amino-2-butynyl) thio-1, 3, 4-thiadiazol-2-yl]-2-carbamates

…, A Abu-Al-Teman, FA Hussein, SR Salman…

文献索引：Zuhair; Abu-Al-Teman; Hussein; Salman; Al-Dujaili; Roche European Journal of Medicinal Chemistry, 1992 , vol. 27, # 2 p. 93 - 99

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被引用次数: 5

摘要

Abstract Three series of 5-thio-1, 3, 4-thiadiazole carbamates containing alkynyl, aminoalkynyl, alkenyl or alkyl thio substituents have been synthesized as potential antimicrobial agents. The influence of both the alkynyl linkage and the various terminal nitrogen heterocyclic moieties on antimicrobial activity was assessed utilizing representative Gram-positive, Gram-negative and fungal species. Mannich base analogs containing a 2- ...