… . 2. Synthesis of 2??(4??benzylpiperazin??1??ylmethyl)??2, 3??dihydro??5H??oxazolo [2, 3–6] quinazolin??5??one and??2, 3??dihydro??5H??thiazolo [2, 3??b] quinazolin??5??one

…, CH Chan, MH Yen, MC Cheng, Y Wang

文献索引：Shiau; Chern; Liu; Chan; Yen; Cheng; Wang Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 5 p. 1467 - 1472

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被引用次数: 17

摘要

Abstract To search for novel antihypertensive heterocycles in the condensed quinazoline series, two representative compounds were synthesized via a suitable reaction sequences. Treating anthranilonitrile with allyl isocyanate gave 2-(allylureido) benzonitrile (10) in a quantitative yield. Compound 10 was cyclized to 3-allylquinazoline-2 (1H, 4 (3H)-dione (11). Bromination of 11 in carbon tetrachloride converted it into the corresponding 3-(2, 3- ...