Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II

C Lee, E Choi, M Cho, B Lee, SJ Oh, SK Park…

文献索引：Lee, Chulho; Choi, Eunhyun; Cho, Misun; Lee, Boah; Oh, Soo Jin; Park, Song-Kyu; Lee, Kiho; Kim, Hwan Mook; Han, Gyoonhee Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4189 - 4192

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被引用次数: 13

摘要

Histone deacetylases (HDACs) are involved in post-translational modification and epi- genetic expression, and have been the intriguing targets for treatment of cancer. In previous study, we reported synthesis and the biological preliminary results of γ-lactam based HDAC inhibitors. Based on the previous results, smaller γ-lactam core HDAC inhibitors are more active than the corresponding series of larger δ-lactam based analogues and the ...