Tetrahedron letters

A novel chemo-enzymatic enantiospecific synthesis of (S)-coriolic acid mediated via immobilized alcohol dehydrogenase of baker's yeast

…, L Dasaradhi, C Muralikrishna, NW Fadnavis

文献索引：Bhalerao, U. T.; Dasaradhi, L.; Muralikrishna, C.; Fadnavis, N. W. Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2359 - 2360

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被引用次数: 9

摘要

Abstract (S)-(E)-(+)-1-Bromo-1-octene-3-ol was prepared in 85% yield and high optical purity (ee 97.4%) via a stereospecific reduction of corresponding bromo vinyl ketone using alcohol dehydrogenase from baker's yeast (EC 1.1. 1.1) and NAD (P) H immobilized on Nucleosil 120-5 C 18, and converted to 13 (S)-hydroxy-9Z, 11E-octadecadienoic (coriolic) acid.