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Cycloalkanones. 3. Structure-activity relations of hypocholesterolemic cyclooctanone derivatives

GL Carlson, IH Hall, GS Abernethy…

文献索引:Carlson,G.L. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 154 - 157

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被引用次数: 8

摘要

The present correlation for the series of compounds listed in Table I does not include the q of the nitrogen atom because every compound in this series has the same (C2H&N (CH1) 2- group. Therefore, a constant q of the nitrogen is assumed. For other series of compounds with N-alkyl derivatives, the q of the nitrogen must be considered as variable, because heteroatoms are considered as active centers for binding with the receptors. However, the ...