Synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives

SN Mokale, RD Elgire, N Sakle, DB Shinde

文献索引：Mokale, Santosh N.; Elgire; Sakle, Nikhil; Shinde, Devanand B. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 682 - 685

全文：HTML全文

被引用次数: 8

摘要

An improved synthetic protocol for a novel series of 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives has been developed using different methods of synthesis. The synthesized compounds are evaluated for their hypolipidemic and hypoglycemic activity by high fat diet induced hyperlipidemia and hyperglycemia in Sprague– Dawley rats.