Total synthesis of the angucycline antibiotics urdamycinone B and 104-2 via a common synthetic intermediate

VA Boyd, GA Sulikowski

文献索引：Boyd, Vincent A.; Sulikowski, Gary A. Journal of the American Chemical Society, 1995 , vol. 117, # 32 p. 8472 - 8473

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被引用次数: 58

摘要

The angucycline family of antibiotics is a large group of biologically active secondary metabolites of microbrial origin.'-3 Urdamycin B, a group member isolated from Streptomyces fradiae, is composed of a trisaccharide attached through a C-glycoside linkage to an angular quinone ring~ ystem.~ Careful acid hydrolysis of urdamycin B led to the loss of two sugars and the isolation of the aglycon urdamycinone B (1). 2a