Bulletin of the Chemical Society of Japan

The reaction of nucleophilic reagents at the. BETA.-position of 3-bromo-4-nitropyridine N-oxides.

E Matsumura, M Ariga

文献索引：Matsumura,E.; Ariga,M. Bulletin of the Chemical Society of Japan, 1977 , vol. 50, p. 237 - 241

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被引用次数: 7

摘要

The reactions of 3-bromo-4-nitro-2-R 1-6-R 2-5-X-pyridine N-oxides (1a: R 1= H, R 2= Me, X= H; 1b: R 1= R 2= Me, X= H; 1c: R 1= R 2= H, X= Br) with diethyl sodiomalonate, ethyl sodiocyanoacetate, and ethyl sodioacetoacetate have been carried out. The treatment of 1a, 1b, and 1c with diethyl sodiomalonate gives 3-[bis (ethoxycarbonyl) methyl]-4-nitro-2-R 1-6- R 2-5-X-pyridine N-oxides (2a, 2b, and 2c) and 4-[bis (ethoxycarbonyl) methyl]-3, 5- ...