Antibacterial and antifungal activity of acyclic and macrocyclic uracil derivatives with quaternized nitrogen atoms in spacers

VE Semenov, AD Voloshina, EM Toroptzova…

文献索引：Semenov; Voloshina; Toroptzova; Kulik; Zobov; Giniyatullin; Mikhailov; Nikolaev; Akamsin; Reznik European Journal of Medicinal Chemistry, 2006 , vol. 41, # 9 p. 1093 - 1101

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被引用次数: 53

摘要

The reactions of 1, 3-bis (α, ω-bromoalkyl)-6-methyluracils with 1, 3-bis (α, ω- ethylaminoalkyl)-6-methyluracils or 1, 3-bis (bromopentyl) thymine with butylamine afforded pyrimidinophanes containing one or two uracil units and nitrogen atoms in bridging polymethylene chains. In some cases individual geometric isomers of pyrimidinophanes differing in the mutual arrangement of the carbonyl and methyl groups at different ...