In a project devoted to the synthesis of new therapeutic agents, we needed a mild and quick approach for the synthesis of functionalized difluoromethylene β-aminovinyl ketones, as useful starting materials for further chemical elaboration. Mostly trifluoromethylated β-aminovinyl ketones are known, and are frequently used as building blocks for heterocyclic synthesis; [6] [7] however, as far as we know, the reactivity of the C-Cl bond of the ...
