Targeting host cell factors required for virus replication provides an alternative to targeting pathogen components and represents a promising approach to develop broad-spectrum antiviral therapeutics. High-throughput screening (HTS) identified two classes of inhibitors (2 and 3) with broad-spectrum antiviral activity against ortho-and paramyxoviruses including influenza A virus (IAV), measles virus (MeV), respiratory syncytial virus (RSV), and human ...
[Harris, Neil V.; Smith, Christopher; Asthon, Michael J.; Bridge, Andrew W.; Bush, Raymond C.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4384 - 4392]
[Harris, Neil V.; Smith, Christopher; Asthon, Michael J.; Bridge, Andrew W.; Bush, Raymond C.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4384 - 4392]