Journal of medicinal chemistry

Synthesis and pharmacological activity of fluorinated tryptamine derivatives

A Kalir, S Szara

文献索引：Kalir,A.; Szara,S. J. Med. Chem., 1963 , vol. 6, p. 716 - 719

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被引用次数: 32

摘要

Condensation of IIb with oxalyl chloride and treatment with diethylamine followed by reduction gave 6-fluoro-S, N-diethyltryptamine. l 2 Pharmacological Findings.-Compounds Ya, b were tested on mice using reserpine-induced ptosis reversal and activity cage tests. I3 In these tests,(see Fig. 1 and 2) Va acted like the parent compound, a-methyltryptamine, but there was a marked decrease in activity especially in the locomotor test with the 6-fluor0 ...