Tetrahedron letters

Catalytic hydrogenation of ethyl 2-amino-2-difluoromethyl-4-cyanobutanoate and its Schiff base reaction modes

J Zhu, BA Price, J Walker, SX Zhao

文献索引：Zhu, Jingyang; Price, Benjamin A.; Walker, Jonathan; Zhao, Shannon X. Tetrahedron Letters, 2005 , vol. 46, # 16 p. 2795 - 2797

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被引用次数: 8

摘要

Under heterogeneous catalysis, ethyl 2-amino-2-difluoromethyl-4-cyanobutanoate or its Schiff base could be selectively reduced in good yield by hydrogenation to give a diamine, or to form a five-membered ring or a six-membered ring heterocycles. This selectivity is highly dependent on the type of catalysts used.